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J E Karp Selected Research

lonafarnib (SCH 66336)

11/2001Current status of clinical trials of farnesyltransferase inhibitors.

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J E Karp Research Topics

Disease

11Leukemia
12/2011 - 03/2000
7Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
12/2015 - 07/2000
6Neoplasms (Cancer)
12/2015 - 07/2001
5Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
09/2007 - 07/2000
2BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia)
11/2001 - 07/2001
2Blast Crisis (Blast Phase)
11/2001 - 07/2001
1Lymphoid Leukemia
09/2007
1Acute Disease
09/2007
1Acute Promyelocytic Leukemia
09/2007
1Myeloproliferative Disorders (Myeloproliferative Disorder)
06/2006
1B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia)
06/2006
1B-Cell Lymphoma (Lymphoma, B Cell)
06/2006
1Acute Erythroblastic Leukemia (Erythroleukemia)
06/2006
1Polycythemia Vera
06/2006
1Central Nervous System Diseases (CNS Diseases)
05/2002
1Aplastic Anemia (Anemia, Hypoplastic)
10/2001
1Body Weight (Weight, Body)
10/2001
1Nausea
07/2001
1Fatigue
07/2001
1Neutropenia
07/2001
1Hematologic Neoplasms (Hematological Malignancy)
07/2001
1Kaposi Sarcoma (Kaposi's Sarcoma)
01/2001
1Inflammation (Inflammations)
01/2001
1Infections
01/2001
1Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (T-ALL)
11/2000
1Precursor B-Cell Lymphoblastic Leukemia-Lymphoma (Leukemia, Pre B Cell)
11/2000
1Breast Neoplasms (Breast Cancer)
07/2000

Drug/Important Bio-Agent (IBA)

5Proteins (Proteins, Gene)FDA Link
01/2004 - 07/2000
3EnzymesIBA
12/2015 - 11/2001
3Farnesyltranstransferase (Farnesyltransferase)IBA
01/2004 - 06/2001
3Biological ProductsIBA
01/2004 - 06/2001
3tipifarnib (R115777)IBA
11/2001 - 06/2001
2DNA (Deoxyribonucleic Acid)IBA
06/2006 - 03/2000
2TransferasesIBA
01/2004 - 07/2001
2Pharmaceutical PreparationsIBA
11/2001 - 12/2000
1pevonedistatIBA
12/2015
1QuinolonesIBA
12/2011
1vosaroxinIBA
12/2011
1Sorafenib (BAY 43-9006)FDA Link
08/2010
1Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
06/2006
1Thrombopoietin (c-mpl Ligand)IBA
06/2006
1ErythropoietinFDA Link
06/2006
1Colony-Stimulating Factor Receptors (Colony-Stimulating Factor Receptor)IBA
06/2006
1Mitogen-Activated Protein KinasesIBA
01/2004
1Cytarabine (Cytosar-U)FDA LinkGeneric
05/2002
1lonafarnib (SCH 66336)IBA
11/2001
1Cyclophosphamide (Cytoxan)FDA LinkGeneric
10/2001
1Antineoplastic Agents (Antineoplastics)IBA
07/2001
1CreatinineIBA
07/2001
1NF-kappa B (NF-kB)IBA
01/2001
1Peptide Hydrolases (Proteases)FDA Link
12/2000
1Initiator CaspasesIBA
12/2000
1RNA (Ribonucleic Acid)IBA
11/2000
1Adenosine Triphosphate (ATP)IBA
07/2000
1Carrier Proteins (Binding Protein)IBA
07/2000
1Messenger RNA (mRNA)IBA
07/2000

Therapy/Procedure

8Therapeutics
09/2007 - 03/2000
3Drug Therapy (Chemotherapy)
05/2002 - 12/2000
2Bone Marrow Transplantation (Transplantation, Bone Marrow)
05/2002 - 10/2001
1Organ Transplantation
01/2001